Adjuvant Nivolumab Shows Potential RFS Benefit Over ipilimumab in Advanced Melanoma

Source: Targeted Oncology, July 2017

In patients with advanced melanoma enrolled in the phase III CheckMate-238 trial, adjuvant nivolumab (Opdivo) extended recurrence-free survival (RFS) compared with adjuvant ipilimumab (Yervoy).

Bristol-Myers Squibb (BMS), the manufacturer of both checkpoint inhibitors, did not release any data, but reported that 3 mg/kg of nivolumab met its primary endpoint at a planned interim analysis by demonstrating superior RFS compared with 10 mg/kg of ipilimumab in patients with stage IIIb/c or stage IV melanoma who are at high risk for recurrence following complete surgical resection. Details will be presented at a future medical meeting.

“These topline results support the potential promise of Opdivo as a treatment option for patients with high-risk surgically resected melanoma,” Vicki Goodman, MD, development lead, melanoma and genitourinary cancers, BMS said in a press release. “There remains an unmet need for additional options as the majority of stage III and resected stage IV high-risk melanoma patients experience disease recurrence after surgery.”

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