Higher Dose of Ipilimumab Improves Survival, But Increases Toxicities in Advanced Melanoma

Source: Targeted Oncology, April 2017

According to results from a randomized, double-blind, phase III study, patients with stage III or IV melanoma assigned to 10 mg/kg ipilimumab (Yervoy) lived longer than patients assigned to a lower dose of the anti-CTLA-4 anticlonal antibody, but at the cost of greater toxicity.1

In the study, performed at 87 medical centers in 21 countries, researchers found that median overall survival (OS) for 364 patients receiving 10 mg/kg of ipilimumab was 15.7 months compared with 11.5 months for 362 patients assigned to 3 mg/kg of ipilimumab (HR = 0.84; 95% CI, 0.70-0.99; P = 0.04).

However, patients in the 10 mg/kg group had a higher incidence of grade 3/4 treatment-related adverse events (AEs), including diarrhea (10% vs 6%), colitis (5% vs 2%), increased alanine aminotransferase (3% vs 1%), and hypophysitis (3% vs 2%).

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