Should Nicotinamide Be Used for Melanoma Prevention?

Source: Cancer Therapy Advisor, September 2017

The risk of an invasive or in situ melanoma diagnosis is continuing to increase, with one recent study estimating the lifetime risk of developing either condition as 1 in 28.1 With this growing risk, the development of chemoprevention strategies against melanoma and other skin cancers is important, especially for those at high risk.

Nicotinamide, a form of vitamin B3 (niacin), is a “promising and well-tolerated” chemopreventive agent for patients at high risk for developing skin cancer, according to the results of a recent review of the agent.2

“Preclinical studies of nicotinamide have demonstrated important anticancer properties including DNA repair and the modulation of inflammation and immune suppression induced by damaging ultraviolet radiation,” Ahmad Tarhini, MD, PhD, director of the Melanoma and Skin Cancer Program at the Cleveland Clinic Taussig Cancer Institute in Ohio, told Cancer Therapy Advisor.

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