Researchers develop new compound that inhibits growth of melanoma cells

Source: News Medical Life Sciences, January 2018

An international team of researchers has developed a novel compound that successfully inhibits growth of melanoma cells by targeting specific epigenetic modifying proteins in these cells.

In the human body cells turn genes on and off by means of chemical modifications that change DNA and related proteins. These epigenetic changes are continuous and are at the core of how healthy cells transform into cancer cells. These modifications contribute to a tumor’s ability to grow indefinitely, as well as making tumor cells drug resistant and capable of surviving treatments intended to kill them.

The new compound, Corin, specifically targets these epigenetic changes in cells and could therefore provide significant improvements in patients without unwanted side effects. These findings appear in the online journal Nature Communications.

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