Risk factors identified for tumor upstaging of melanoma

Source: Healio, July 2017

Anatomic location and subtotal diagnostic biopsies were the greatest risk factor for upstaging of melanoma, according to recently published study results in the Journal of the American Academy of Dermatology.

“When residual melanoma remains after the diagnostic biopsy, upstaging (defined as an increase in the T stage designated by the American Joint Committee on Cancer) might be detected after wide local excision in 5% to 22% of cases,” researchers at the University of Pennsylvania, wrote. “Upstaging might complicate patients counseling about prognosis and surgical management of melanoma.”

The researchers conducted a retrospective cross-sectional study of patients (mean age, 60.8; 57.6% men) with 1,332 consecutive in situ to T4a biopsy-proven melanomas treated with wide local excision.

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