Survival Gain With Higher Ipilimumab Dose Offers Opportunity for Some Melanoma Patients

Source: OncLive, April 2017

Patients with stage III or IV melanoma assigned to 10 mg/kg ipilimumab (Yervoy) lived longer than patients assigned to a lower dose of the anti-CTLA-4 anticlonal antibody, but at the cost of greater toxicity.1

In results from a randomized, double-blind, phase III study performed at 87 medical centers in 21 countries, researchers found that median overall survival (OS) for 364 patients receiving 10 mg/kg of ipilimumab was 15.7 months compared with 11.5 months for 362 patients assigned to 3 mg/kg of ipilimumab (HR = 0.84; 95% CI, 0.70-0.99; P = 0.04).

However, patients in the 10 mg/kg group had a higher incidence of grade 3/4 treatment-related adverse events (AEs), including diarrhea (10% vs 6%), colitis (5% vs 2%), increased alanine aminotransferase (3% vs 1%), and hypophysitis (3% vs 2%).

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